复制缺陷型狂犬病毒(RABV)可快速和有效激发在小鼠体内由T细胞依赖和非T细胞依赖机制产生的病毒中和抗体滴度,因此有望用于研制狂犬病毒暴露后疫苗。为了促进这种早期有效的B细胞激活,我们假设,活RABV研制的疫苗可直接感染B细胞,从而活化大量的抗原提呈细胞(APCs),APCs可在早期启动并且共同刺激CD4+T细胞。在本报道中,我们用活RABV研制的疫苗载体有效感染来自出生早期的小鼠和人类的B细胞。与感染模型或用灭活RABV疫苗处理细胞相比较,B细胞感染导致了B细胞激活和抗原呈递早期标志的明 Replication-deficient rabies virus (RABV) can rapidly and efficiently stimulate virus-neutralizing antibody titers generated by T-cell dependent and non-T cell dependent mechanisms in mice and is therefore expected to be used in the development of rabies virus post-exposure vaccines. To facilitate this early and effective B-cell activation, we hypothesized that vaccines developed by live RABV would directly infect B cells, activating large numbers of antigen presenting cells (APCs) that could be activated early and co-stimulated with CD4 + T cells. In this report, we used the vaccine vector developed by live RABV to efficiently infect B cells from mice and humans that were born early. Infection with B cells results in B cell activation and early signs of antigen presentation as compared to infected models or cells treated with an inactivated RABV vaccine