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目的探讨高尿酸血症和高甘油三酯血症对冠状动脉病变风险的联合评估价值。方法对195例冠心病患者和69例非冠心病患者进行对比研究,分析尿酸和甘油三酯(TG)水平的差异。结果冠心病患者的尿酸及TG水平高于对照组。经多元逐步回归分析显示年龄、糖尿病、纤维蛋白原和尿酸与冠状动脉病变程度存在有意义的回归关系。联合评估发现高尿酸水平(≥416μmol/L)及高TG水平(≥2.33mmol/L)的患者发生冠状动脉事件的风险较单一指标发生冠状动脉事件的风险明显增加,OR值为3.13。糖尿病患者在相应的尿酸和TG水平下,冠状动脉病变程度明显升高。结论联合应用尿酸和TG评估急性冠状动脉事件的发生可能有一定意义。综合考虑患者体内的嘌呤代谢和脂质代谢,尤其对于糖尿病患者更为重要,也更有利于临床医师合理评价冠状动脉风险。
Objective To investigate the combined evaluation of the risk of coronary artery disease with hyperuricemia and hypertriglyceridemia. Methods 195 patients with coronary heart disease and 69 patients with non-coronary heart disease were compared to study the differences of uric acid and triglyceride (TG) levels. Results The levels of uric acid and TG in CHD patients were higher than those in control group. Multiple stepwise regression analysis showed that age, diabetes, fibrinogen and uric acid and coronary artery disease there is a significant degree of regression. The combined assessment found that the risk of coronary events was significantly increased in patients with high uric acid levels (≥416 μmol / L) and high TG levels (≥2.33 mmol / L) as compared with those with a single indicator of coronary events (OR = 3.13). Diabetic patients in the corresponding uric acid and TG levels, coronary artery lesions significantly increased. Conclusion The combined application of uric acid and TG in the assessment of acute coronary events may have some significance. Comprehensive consideration of the patient’s purine metabolism and lipid metabolism, especially for diabetic patients is more important, but also more conducive to clinicians a reasonable assessment of coronary risk.