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目的:比较三种可治疗口腔念珠菌病药物的临床疗效。方法:对2009年6月～2011年8月期间在我院进行治疗的216例口腔念珠菌病患者的临床资料进行回顾性研究。我们将这216例患者随机分为A组、B组和C组,其中,A组有72例患者,B组有64例患者,C组有80例患者。A组患者使用制霉菌素进行治疗,B组患者使用酮康唑进行治疗,C组患者使用氟康唑进行治疗。治疗结束后,对三组患者的治疗效果和发生不良反应的情况进行比较。结果:经过治疗,A组、B组和C组患者治疗的总有效率分别为97.22%、65.63%和97.50%。其中,A组患者治疗的总有效率与C组患者相比无显著性差异(p>0.05),而A组患者和C组患者治疗的总有效率均明显高于B组患者,二者相比差异具有显著性(p<0.05)。在治疗期间,A组、B组和C组患者发生不良反应的几率分别为5.56%,12.5%和2.50%。其中,A组患者发生不良反应的几率与C组患者相比无显著性差异(p>0.05),而A组患者和C组患者发生不良反应的几率均明显低于B组患者,二者相比差异具有显著性(p<0.05)。结论:用制霉菌素和氟康唑治疗口腔念珠菌病疗效确切,而且引起不良反应的几率较低,值得在临床上推广使用。
Objective: To compare the clinical efficacy of three drugs that can treat oral candidiasis. Methods: The clinical data of 216 patients with oral candidiasis who were treated in our hospital from June 2009 to August 2011 were retrospectively studied. We divided the 216 patients into groups A, B and C randomly, with 72 patients in group A, 64 patients in group B, and 80 patients in group C. Patients in group A were treated with nystatin, patients in group B were treated with ketoconazole, and patients in group C were treated with fluconazole. After treatment, the three groups of patients with treatment and adverse reactions were compared. Results: After treatment, the total effective rates of treatment in group A, group B and group C were 97.22%, 65.63% and 97.50%, respectively. Among them, the total effective rate of treatment in group A was not significantly different from that in group C (p> 0.05), while the total effective rate of treatment in group A and group C was significantly higher than that in group B The difference was significant (p <0.05). The odds of adverse reactions in groups A, B, and C were 5.56%, 12.5%, and 2.50%, respectively, during treatment. Among them, the incidence of adverse reactions in group A patients was not significantly different from that in group C patients (p> 0.05), while the incidence of adverse reactions in group A patients and group C patients was significantly lower than that in group B patients The difference was significant (p <0.05). Conclusion: The treatment of oral candidiasis with nystatin and fluconazole has definite effect and low risk of adverse reactions, which is worth to be popularized clinically.