Crigler－Najjar病是一种常染色体隐性遗传性疾病，是由肝脏胆红素—尿嘧啶—5’—二磷酸葡萄糖醛酸转移酶（bUGT）绝对（Ⅰ型）或相对（Ⅱ型）缺乏所引起的。自采用光疗和／或苯巴比妥等治疗以来，虽取得一定效果，但仍存在诸如皮肤损伤、细胞内DNA受损及影响细胞色素P450代谢 Crigler-Najjar disease is an autosomal recessive disease consisting of liver bilirubin-uracil-5’-diphosphate glucuronosyltransferase (bUGT) absolute (type I) or relative (type II) deficiency Caused by. Since the use of phototherapy and / or phenobarbital and other treatment, although some results, but there are still such as skin damage, damage to intracellular DNA and affect the metabolism of cytochrome P450