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目的 :观察不同剂量静脉注射免疫球蛋白 (IVIG)辅助治疗狼疮性肾炎 (LN )的疗效。方法 :67例LN患者随机分成A、B、C3组进行治疗 ,3组均同样使用激素和环磷酰胺 (CTX) ,B组联用大剂量IVIG治疗 ,C组联用中小剂量IVIG治疗 ;对比不同治疗方案对SLE疾病活动指数 (SLEDAI)、尿蛋白及院内感染情况的影响。结果 :B、C组在降低SLEDAI、降低尿蛋白、降低院内感染方面明显优于A组 (P <0 0 5 ) ,而B、C两组间差异无显著性 (P >0 0 5 )。结论 :IVIG辅助治疗LN ,不论是使用大剂量还是中小剂量 ,在控制LN活动和防治感染方面均有明显疗效
Objective: To observe the curative effect of different doses of intravenous immunoglobulin (IVIG) adjuvant treatment of lupus nephritis (LN). Methods: Sixty-seven patients with LN were randomly divided into three groups: group A, B and C3. Hormone and cyclophosphamide (CTX) were also used in the three groups. Group B was treated with high dose IVIG and group C was treated with medium and small doses of IVIG. Effects of different treatment regimens on SLE disease activity index (SLEDAI), urinary protein and nosocomial infections. Results: In group B and group C, SLEDAI was significantly lower than that of group A (P <0 05), but no significant difference was found between group B and C (P 0 05). Conclusion: IVIG adjuvant treatment of LN, whether using a large dose or a small dose, has significant effects in controlling LN activity and preventing and treating infection