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目的:比较脂多糖-被动血凝试验(LPS-PHA)、肥达反应和细菌培养诊断伤寒的临床价值。方法:用上述三种方法同时对102例伤寒患者和250例非伤寒发热患者进行检测。结果:①伤寒患者中LPS-PHA阳性率为92.2%,肥达反应阳性率为88.2%,差异无显著性(P>0.05),但均高于细菌培养的阳性率(24.5%,P<0.01)。②病程第1周三种方法的阳性率分别为80%(24/30)、83%(25/30)和27%(8/30)。③肥达反应的伤寒与副伤寒鞭毛抗体交叉阳性率达37.3%。结论:细菌培养的灵敏度太低,肥达反应的特异性较差,LPS-PHA早期快速诊断伤寒可靠性较好。
Objective: To compare the clinical value of lipopolysaccharide-passive hemagglutination test (LPS-PHA), Widal reaction and bacterial culture in the diagnosis of typhoid fever. Methods: 102 cases of typhoid fever and 250 cases of non-typhoid fever were tested simultaneously by the above three methods. Results (1) The positive rate of LPS-PHA in typhoid fever was 92.2%, the positive rate of Wadda reaction was 88.2%, but the difference was not significant (P> 0.05), but higher than the positive rate of bacterial culture 24.5%, P <0.01). ② The first week of disease duration of the three methods were 80% (24/30), 83% (25/30) and 27% (8/30) respectively. ③ fat-reactive typhoid and paratyphoid flagellum antibody cross-positive rate of 37.3%. Conclusion: The sensitivity of bacterial culture is too low, and the specificity of Widal reaction is poor. The early diagnosis of typhoid fever with LPS-PHA is reliable.