细粒棘球绦虫原虫节受浓度为0.05～1μg/ml的吡喹酮作用后,其皮层即出现肿胀、空泡,严重者还发生破裂,脱落并暴露肌层或实质组织;部分细胞显示核浓缩,溶解及崩裂。该药还能迅速引起原头节体内糖原含量的减少以及AKP和ATP酶活力的减弱,但对虫体核酸及蛋白质的作用则发生较慢或影响较小。初步认为吡喹酮的体外杀虫作用主要是通过药物破坏原头节的皮层并抑制虫体的糖代谢而实现的。 Echinococcus granulosus was exposed to praziquantel at a concentration of 0.05 ~ 1μg / ml. The cortex of the Echinococcus granulosus was swollen and vacuolized, and in severe cases, ruptured, exfoliated and exposed muscle or parenchyma; some cells showed nuclear Concentrate, dissolve and crack. The drug can also rapidly cause the reduction of glycogen content and AKP and ATPase activity of the original head, but the effect on the nucleic acid and protein of the parasites is slower or less affected. Preliminary thought praziquantel insecticidal effect in vitro mainly through the destruction of the protoscoleces of the drug cortex and inhibit the body’s sugar metabolism and achieve.