儿童时期糖尿病(IDDM)患儿由于胰岛素分泌障碍,造成其体内糖、脂质和蛋白质代谢的严重紊乱.其中葡萄糖代谢异常即表现出高血糖、渗透性利尿、烦渴、体重下降等症状;脂质代谢异常则加速酮体生成、造成酮症酸中毒.前者已为众所周知,本文仅讨论IDDM患儿的脂质代谢紊乱及其在酮症酸中毒发展过程中的作用.人体中调节葡萄糖代谢的主要激素有胰岛素、胰高血糖素、肾上腺素、去甲肾上腺素、皮质醇和生长激 Children with childhood diabetes mellitus (IDDM) develop severe disorders in the metabolism of sugar, lipid and protein due to impaired insulin secretion, with abnormal glucose metabolism, such as hyperglycemia, osmotic diuresis, polydipsia, and weight loss. Metabolic abnormalities accelerate ketone body formation, resulting in ketoacidosis.The former is already well known, this article discusses only the IDDM children with lipid metabolism disorder and its role in the development of ketoacidosis in the body to regulate glucose metabolism The main hormones are insulin, glucagon, epinephrine, norepinephrine, cortisol and growth factor