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乙型肝炎病毒(HBV)的包膜蛋白依次由108—115氨基酸的前S1蛋白、55氨基酸的前S2蛋白和226氨基酸的S蛋白组成。前S1蛋白的N端既含有直接介导毒粒与肝细胞膜结合的位点,又含有许多免疫原性较强的T细胞与B细胞表位,抗前S1抗体水平还是HBV血清学检查的一项重要指标。
The envelope protein of Hepatitis B virus (HBV) consists of pre-S1 protein of 108-115 amino acids, pro-S2 protein of 55 amino acids and S protein of 226 amino acids in turn. The N-terminus of pre-S1 protein not only contains the direct site of drug-mediated hepatocyte membrane binding, but also contains many highly immunogenic T cells and B-cell epitopes. The level of anti-S1 antibody or HBV serology Key indicators.