目的:采用紫外分光光度法测定国产盐酸氟西汀胶囊的溶出度。方法:照中华人民共和国药典1995年版二部附录所述的溶出度测定转篮法,转速为75r/min,水为溶剂,取样时间为30min,测定波长为226nm,测定结果用空胶壳作空白校正。结果:盐酸氟西汀水溶液在4.5～22.5μg/ml浓度范围内吸收度与浓度呈良好线性关系,回归方程Y=0.03576X—0.001,γ=0.9999,回收率为100.1％,CV=0.46％(n=5),溶出限度大于80％。结论:本方法具有操作简单、快速,结果准确的优点,适用于盐酸氟西汀胶囊生产的质量控制。 Objective: To determine the dissolution of domestic fluoxetine hydrochloride capsules by UV spectrophotometry. Methods: According to the People’s Republic of China Pharmacopoeia 1995 edition two appendix described dissolution test basket method, speed 75r / min, water as solvent, sampling time was 30min, the measured wavelength was 226nm, the determination of the blank shell with blank Correction. Results: The linear range of fluoxetine hydrochloride solution was 4.5-22.5μg / ml, the regression equation was Y = 0.03576X-0.001, γ = 0.9999, the recovery was 100.1%, CV = 0.46% n = 5), dissolution limit greater than 80%. Conclusion: The method has the advantages of simple, rapid and accurate results, and is suitable for the quality control of fluoxetine hydrochloride capsules.