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所有各种类型癫痫发作都和某群神经元过度同步或持续的放电活动有关。这就必然和神经元的突触活动有联系。癫痫发作时突触功能变化可能是原发的,也可能继发于异常神经元的放电。在用药物或其它毒性因子引起癫痫发作实验中,通过神经化学方法的鉴定,发现突触传递有增减现象。此现象的分子机理无疑是由特殊的神经递质系统所致。下面拟从中枢神经递质角度来探讨癫痫发作和抗惊厥剂的作用机理。这些递质(包括公认的和有争议的)是
All types of seizures have been associated with over-synchronic or sustained discharge events in a group of neurons. This must be related to the synaptic activity of neurons. Changes in synaptic function during epileptic seizures may be primary, may also be secondary to the discharge of abnormal neurons. In the experiment of seizure induced by drugs or other toxic factors, there was an increase or decrease of synaptic transmission through the identification of neurochemical methods. The molecular mechanism of this phenomenon is undoubtedly caused by a special neurotransmitter system. The following is intended to explore the mechanism of seizures and anticonvulsants from the perspective of CNS neurotransmitters. These transmitters (including recognized and controversial) are