论文部分内容阅读
目的探讨依地酸钙钠(EDTA)驱铅治疗慢性铅中毒患者肾损害的保护作用。方法对52例慢性轻度铅中毒者连续3年用EDTA驱铅治疗,并对其进行血铅(PbB)、红细胞锌卟啉(ZPP)、尿β2-微球蛋白(U-β2-MG)、尿视黄醇结合蛋白(U-RBP)、尿N-乙酰-β-D-氨基葡萄糖苷酶(U-NAG)监测。结果慢性铅中毒患者PbB、ZPP、U-β2-MG、U-NAG、U-RBP分别为(595.36±134.34)μg/L、(4.16±1.96)μmol/L、(564.02±224.32)μg/(g.Cr)、(31.91±13.37)U/(g.Cr)、(584.38±238.82)μg/(g.Cr)均显著高于对照组〔分别为(123.53±49.14)μg/L、(1.33±0.99)μmol/L、(139.26±66.62)μg/(g.Cr)、(11.83±3.7)U/(g.Cr)、(158.7±61.5)μg/(g.Cr)〕(P<0.01);连续3年用EDTA驱铅治疗后,U-β2-MG、U-NAG、U-RBP逐年下降,不同时间比较其检测结果差异有统计学意义(P<0.01)。结论用EDTA驱铅治疗可逆转慢性铅中毒患者的肾损害。
Objective To investigate the protective effect of edetate calcium-lead (EDTA) on kidney damage in patients with chronic lead poisoning. Methods Fifty-two patients with chronic mild lead poisoning were treated with EDTA for 3 consecutive years. Blood Pb (Pb), ZPP, U-β2-MG , Urinary retinol binding protein (U-RBP) and urine N-acetyl-β-D-glucosaminidase (U-NAG) Results The levels of PbB, ZPP, U-β2-MG, U-NAG and U-RBP in patients with chronic lead poisoning were (595.36 ± 134.34) μg / (31.91 ± 13.37) U / (g.Cr), (584.38 ± 238.82) μg / (g.Cr) were significantly higher than those in the control group (123.53 ± 49.14 μg / L and 1.33 ± 0.99) μmol / L, (139.26 ± 66.62) μg / (g.Cr), (11.83 ± 3.7) U / (g.Cr), (158.7 ± 61.5) μg / ). U-β2-MG, U-NAG and U-RBP decreased gradually after treated with EDTA for 3 years in a row. The difference was statistically significant at different time points (P <0.01). Conclusion Lead excretion with EDTA can reverse renal damage in patients with chronic lead poisoning.