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蛋白质酪氨酸磷酸酶(PTP)是胰岛素受体(IR)及其原始细胞基质脱磷酸化所必需的,PTP活性异常与胰岛素抵抗状态有关。新近有报道认为,PTP-1B在肥胖和Ⅱ型糖尿病(DM2)者胰岛素抵抗的发病机理中起一定作用。本研究旨在证明DM2肥胖者与非DM2肥胖者脂肪组织中PTP-1B活性可能是异常的。
Protein tyrosine phosphatase (PTP) is required for insulin receptor (IR) and dephosphorylation of its original cellular matrix, and PTP activity is associated with insulin resistance. It has recently been reported that PTP-1B plays a role in the pathogenesis of insulin resistance in obese and type 2 diabetic (DM2) patients. This study was designed to demonstrate that PTP-1B activity may be abnormal in adipose tissue between DM2-obese and non-DM2 obese subjects.