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目的··:就盐酸纳曲酮防止阿片类成瘾脱毒后复发的效能进行再评价。方法··:1088例完成脱毒治疗的海洛因依赖者给予纳曲酮治疗。药物剂量相对固定在40-50mg·d-1,并随患者反应调整。治疗期间定期门诊或出诊随访。结·果·:服用纳曲酮6个月的保持率为33.4%,与自身同期操守率(2.4%)比较具有显著性差异。服用纳曲酮后,再吸海洛因的欣快感、渴求程度及偶吸海洛因的发生率均降低。纳曲酮的不良反应轻,包括:睡眠障碍、消化系统症状和乏力,少数患者转氨酶呈一过性增高。在纳曲酮治疗的同时给予积极的家庭支持和社会帮教,提供生活和就业技能的指导,减少偶吸的机会等措施,有助于提高服药保持时间。结论··:进一步证实了纳曲酮对预防我国阿片类依赖者脱毒后复吸具有肯定的辅助治疗作用。
Objective · ·: To re-evaluate the efficacy of naltrexone hydrochloride in preventing relapse after detoxification of opiates. Methods · · ·: 1088 cases of heroin addicts who completed detoxification were given naltrexone. Drug dose is relatively fixed at 40-50mg · d-1, and adjusted with the patient’s response. Regular outpatient visits or visits during treatment. Results and Results: The retention rate of naltrexone taken at 6 months was 33.4%, which was significantly different from that of naltrexone (2.4%) during the same period. After taking naltrexone, re-absorption of heroin euphoria, craving and the incidence of heroin escalation are reduced. Adverse reactions to naltrexone are mild, including: sleep disorders, digestive symptoms and weakness, and a minority of patients with transient elevated transaminases. Naltrexone treatment while giving active family support and social help, providing life and employment skills guidance, reduce the chances of even suck, and help to improve medication retention time. Conclusion ··: Naltrexone further confirmed that the prevention of opioid dependence relapse after detoxification has a positive effect of adjuvant therapy.