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目的:探讨干扰素a-2b联合阿昔洛韦滴眼液对单纯疱疹病毒性角膜炎(HSK)患者血浆T细胞亚群的影响及疗效观察。方法:对34例HSK患者(治疗组)患者予以0.1%阿昔洛韦滴眼液局部滴患眼,每天6次;并予以重组人干扰素α-2b 10万~U球结膜下注射,隔天1次,每次1 ml,共8次;同时予以干扰素100万~Uim,qod,共8次。观察治疗前后检测患者外周血T细胞亚群的变化,并进行临床疗效的评定及不良反应观察。另选择30例正常健康体检者作为对照组。结果:与对照组相比较,治疗组患者治疗前外周血CD_4~+明显减少,CD_8~+明显增加,CD_4~+/CD_8~+比值明显下降(P<0.05或P<0.01)。治疗后患者外周血CD_4~+明显增加,CD_8~+明显减少,CD_4~+/CD_8~+比值明显增加,与治疗前比较有明显统计学差异(P<0.05或<0.01)。结论:干扰素α-2b联合阿昔洛韦滴眼液治疗HSK的疗效确切,无严重不良反应。作用机制与通过调节T细胞亚群紊乱,改善T细胞的功能,提高细胞免疫反应有关。
Objective: To investigate the effect of interferon α-2b combined with acyclovir eye drops on plasma T lymphocyte subsets in patients with herpes simplex keratitis (HSK) and its therapeutic effect. Methods: Thirty-four patients with HSK (treatment group) were treated with 0.1% acyclovir eye drop, which was infused 6 times a day. The patients were given subconjunctival injection of recombinant interferon alpha-2b 1 times a day, each 1 ml, a total of 8 times; the same time to interferon 1 million ~ Uim, qod, a total of 8 times. The changes of T lymphocyte subsets in peripheral blood were detected before and after treatment, and the clinical efficacy and adverse reactions were observed. Another 30 cases of normal health examination as a control group. Results: Compared with the control group, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 ~ + ratio of the treated group were significantly decreased before treatment (P <0.05 or P <0.01). After treatment, CD_4 ~ + in peripheral blood of patients was significantly increased, CD_8 ~ + was significantly decreased, and the ratio of CD_4 ~ + / CD_8 ~ + was significantly increased compared with that before treatment (P <0.05 or <0.01). Conclusion: Interferon α-2b combined with acyclovir eye drops treatment of HSK exact effect, no serious adverse reactions. Mechanism of action and by regulating T cell subsets disorders, improve T cell function, improve cellular immune response.