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目的研究HSP60、HSP70在慢性胰腺炎组织及不同分化胰腺癌组织中的表达及其意义。方法应用免疫组织化学研究1997年1月～2003年1月本院外科手术切除慢性胰腺炎组织12例,胰腺腺癌及癌旁组织63例中HSP60、HSP70的表达。结果HSP60和HSP70在胰腺癌中的过表达率与癌旁组织、慢性胰腺炎组织相比差异有显著性；HSP70的过表达率与是否发生淋巴结转移有显著关系。结论细胞内HSP加和HSP90表达增加是判断胰腺癌预后的重要指标。
Objective To study the expression and significance of HSP60 and HSP70 in chronic pancreatitis and differentiated pancreatic cancer. Methods Immunohistochemistry was used to study the expression of HSP60 and HSP70 in 12 cases of chronic pancreatitis and 63 cases of pancreatic adenocarcinoma and adjacent normal tissue from January 1997 to January 2003 in our hospital. Results The overexpression rates of HSP60 and HSP70 in pancreatic cancer were significantly different from those in paracancerous tissues and chronic pancreatitis tissues. The overexpression rate of HSP70 was significantly correlated with lymph node metastasis. Conclusion The increase of intracellular HSP and HSP90 expression is an important index to judge the prognosis of pancreatic cancer.