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已经证实烧伤后免疫反应的显著改变与损伤程度有关,而且常被认为是引起严重烧伤患者创面脓毒症恶化而死亡的原因。然而,对这种免疫学改变的精确机理,是免疫缺陷还是免疫抑制,却存在着不同见解。作者设计本研究旨在说明烧伤所致表型性和功能性免疫改变,并阐明有关的特异性细胞缺陷。研究对象:伤后24～48小时内住院的严重烧伤患者30名(烧伤总面积30～84％),取肝素化静脉血。51名健康人作为对照。
It has been demonstrated that significant changes in the post-burn immune response are related to the extent of the injury and are often thought to be responsible for the worsening of the wound sepsis in severely burned patients. However, the precise mechanism of such immunological changes is immunodeficiency or immunosuppression, but different opinions exist. Authors’ Designs The aim of this study was to demonstrate the role of burn-induced phenotypic and functional immune changes and to elucidate the specific cell defects involved. PARTICIPANTS: Thirty (30% -84%) patients with severe burns hospitalized within 24 to 48 hours after injury were enrolled. Heparinized venous blood was obtained. 51 healthy people as a control.