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目的探讨还原型谷胱甘肽(GSH)治疗新生儿黄疸的疗效及安全性。方法 82例新生儿黄疸患儿,采用数字随机表将患儿分为对照组和观察组,各41例。对照组予以常规治疗,观察组在对照组基础上予以GSH治疗,记录治疗后血清胆红素水平及恢复正常时间,观察两组治疗效果及不良用药反应。结果观察组治疗总有效率为95.12%显著高于对照组的80.49%,差异具有统计学意义(P<0.05);观察组治疗后血清胆红素水平为(126.32±12.59)μmol/L较对照组低,恢复正常时间为(8.12±2.31)d较对照组短,差异均具有统计学意义(P<0.05)。结论 GSH治疗新生儿黄疸安全有效,能够降低血清胆红素水平,提高临床疗效,临床可推广应用。
Objective To investigate the efficacy and safety of reduced glutathione (GSH) in the treatment of neonatal jaundice. Methods A total of 82 neonates with jaundice were enrolled in this study. The children were divided into control group and observation group by digital randomized table, 41 cases in each group. The control group was given routine treatment. The observation group was treated with GSH on the basis of the control group. The serum bilirubin level and the recovery time were recorded. The therapeutic effect and adverse drug reaction were observed in both groups. Results The total effective rate of the observation group was 95.12%, which was significantly higher than that of the control group (80.49%, P <0.05). The serum bilirubin level in the observation group was (126.32 ± 12.59) μmol / L, (8.12 ± 2.31) d were shorter than control group, the differences were statistically significant (P <0.05). Conclusion GSH treatment of neonatal jaundice safe and effective, can reduce serum bilirubin levels and improve clinical efficacy, clinical application.