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目的:优选肠尔舒结肠定位释药胶囊中黄柏、黄连提取工艺。方法:以出固率和盐酸小檗碱的得率为指标,单因素试验考察乙醇回流提取法、水煎煮提取法、渗漉提取法对黄柏、黄连提取效率的影响;选取乙醇体积分数、乙醇用量、提取次数、提取时间为考察因素,采用正交试验优选肠尔舒结肠定位释药胶囊中黄柏、黄连提取工艺。结果:选择乙醇回流法进行提取,最佳提取工艺为8倍量50%乙醇回流提取3次,每次2 h。结论:该优选工艺稳定可靠、重复性良好,为肠尔舒结肠定位释药胶囊中有效成分的提取提供试验依据。
OBJECTIVE: To optimize the extraction process of Cortex Phellodendri and Coptis Chinensis in the capsule of Gut Er Shu colon. Methods: Taking the yield and the yield of berberine hydrochloride as indexes, the effects of ethanol reflux extraction, decoction by boiling water and percolation extraction on the extraction efficiency of cork and berberine were studied by single factor experiment. Ethanol dosage, extraction times and extraction time were investigated. The orthogonal experiment was used to optimize the extraction process of Cortex Phellodendri and Coptis chinensis Franch. Results: The ethanol extraction method was selected for extraction. The best extraction process was 8 times the amount of 50% ethanol reflux extraction 3 times, each time 2 h. Conclusion: The optimal process is stable and reliable with good repeatability, which provides the experimental basis for the extraction of the active ingredients in the colon-gut-releasing capsule of gan Er Shu.