随着临床医学的进展,目前应用于临床的新药越来越多,另一方面,许多老药,其新的药理作用被逐步认识和发现,还意外发现一些药物的副作用对某些疾病有治疗作用,简单介绍一些老药的临床新应用概况。一、抑制前列腺素合成药: 阿斯匹林。近年发现炎症、疼痛、血小板凝集等都与前列腺素有关。除能抑制前列腺素的合成外,阿斯四林还能抑制ADP的释放。用于防治动脉硬化症,能减少脑缺血发作次数和预防脑梗塞、心肌梗塞。阿斯匹林并用抗凝剂治疗脑血栓,可减少脑血栓的发病而不增加颅内出血的危险。阿斯匹林与潘生丁合用于人工瓣膜置换术者,可减少或阻止术后血小板沉积于瓣膜上。在断肢再植、带血管游离皮瓣移植术后,为 With the progress of clinical medicine, there are more and more new drugs applied to the clinic at present. On the other hand, many new drugs have been gradually recognized and found out by their new pharmacological effects. Some drugs have also been unexpectedly found to have side effects on certain diseases Role, a brief introduction of some new clinical application of the old drug. First, inhibit prostaglandin synthesis medicine: aspirin. In recent years, inflammation, pain, platelet aggregation and so on are related to prostaglandin. Aspirin also inhibits the release of ADP in addition to inhibiting prostaglandin synthesis. For the prevention and treatment of atherosclerosis, can reduce the number of ischemic attacks and prevent cerebral infarction, myocardial infarction. Aspirin and anticoagulant therapy for cerebral thrombosis, can reduce the incidence of cerebral thrombosis without increasing the risk of intracranial hemorrhage. Aspirin and dipyridamole are candidates for prosthetic valve replacement to reduce or prevent postoperative platelet deposition on the valve. Replantation of severed limbs, with vascular free flap transplantation, for