去甲肾上腺素转运蛋白是交感神经信号传递途径中的重要环节,主要功能是将神经元释放的去甲肾上腺素重新摄取回突触前膜中,通过这种方式调控神经递质信号强度。心脏交感神经去甲肾腺素转运蛋白功能异常对心力衰竭恶化、进展发挥重要作用。心力衰竭时去甲肾上腺素转运蛋白功能异常可能与交感神经去神经、神经元表面表达降低、内化、转录后异常、氧化负荷增加、细胞因子对心脏交感神经的损伤作用有关。 Norepinephrine transporter is an important part of the sympathetic signaling pathway, the main function is to re-up norepinephrine released by neurons back to the presynaptic membrane, in this way regulate the signal intensity of neurotransmitters. Cardiac sympathetic dysfunction of norepinephrine transporter plays an important role in the progression and progression of heart failure. The dysfunction of norepinephrine transporters in heart failure may be related to the denervation of sympathetic denervation, neuronal surface expression, abnormal internalization, post-transcriptional abnormality, increased oxidative stress, and the cytotoxic effects on cardiac sympathetic nerve.