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目的探讨血清超氧化物岐化酶(SOD)、丙二醛(MDA)、维生素C(Vit-C)、维生素E(Vit-E)浓度变化与结缔组织病(connectivetissuedisease,CTD)的关系。方法本实验以化学比色法分别检测了99例CTD患者的血清SOD、MDA、维生素C、维生素E的浓度,与正常对照组进行了比较。其中系统性红斑狼疮(SLE)患者活动期与非活动期进行了比较。结果99例CTD患者,其中系统性红斑狼疮组(SLE)23例,原发性干燥综合征组(SS)21例,类风湿性关节炎组(RA)20例,混合结缔组织病组(MCTD)13例,多发性肌炎组(PM)13例,进行性系统性硬化症组(PSS)9例,各CTD组血清MDA浓度较正常对照组增高(P<0.01),其中SLE活动期MDA浓度较非活动期增高(P<0.01)。而各组血清SOD、维生素C、维生素E浓度较正常对照组降低(P<0.001、P<0.05、P<0.001),其中SLE活动期血清SOD、维生素C、维生素E浓度也较非活动期下降(P<0.01,P<0.05,P<0.05)。结论血清SOD、MDA、维生素C,维生素E水平的变化与CTD的发生发展及SLE的活动性有关。血清MDA水平升高,SOD、维生素C、维生素E抗氧化水平降低是CTD的危险因素。
Objective To investigate the relationship between serum SOD, MDA, Vit-C and Vit-E and connective tissue disease (CTD). Methods In this experiment, the serum levels of SOD, MDA, vitamin C and vitamin E in 99 cases of CTD patients were detected by chemical colorimetry respectively, and compared with the normal control group. Including systemic lupus erythematosus (SLE) patients were active and inactive period were compared. Results Totally 99 patients with CTD were diagnosed as systemic lupus erythematosus (SLE), 21 as primary sjogren syndrome (SS), 20 as rheumatoid arthritis (RA), mixed connective tissue disease (MCTD) ) 13 cases, 13 cases of polymyositis group (PM) and 9 cases of progressive systemic sclerosis (PSS). The levels of serum MDA in each CTD group were higher than those in normal control group (P <0.01) The concentration was higher than inactive (P <0.01). The levels of serum SOD, vitamin C and vitamin E in each group were lower than those in the normal control group (P <0.001, P <0.05, P <0.001), and the concentrations of serum SOD, vitamin C and vitamin E in active SLE were also lower than those in inactive phase (P <0.01, P <0.05, P <0.05). Conclusion The changes of serum SOD, MDA, vitamin C and vitamin E levels are related to the occurrence and development of CTD and the activity of SLE. Serum MDA levels increased, SOD, vitamin C, vitamin E level of anti-oxidation is a risk factor for CTD.