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动态观察了３种致纤维化能力不同的处理因素（硅尘，煤硅尘和磷酸羟基哌喹十硅尘）对实验性大鼠矽肺，煤矽肺支气管肺泡冲洗液中肺表面活性物质的影响和所致肺组织病理改变。结果表明致纤维化能力强的硅尘对肺表面活性物质系统影响明显，致纤维化作用弱的煤硅尘对肺表面活性物质系统影响弱，作者认为肺表面活性物质系统和尘肺的发生发展有一定的关系，肺内早期非特异性的炎症反应可能和该系统的功能活跃有关。
The effect of three different treatment factors (silica dust, coal dust and hydroxyaproquadoxime) on the pulmonary surfactant in rat silicosis and coal-silicosis bronchoalveolar lavage fluid were dynamically observed. Pathological changes caused by lung tissue. The results show that the fibrinolytic ability of silicon dust on the pulmonary surfactant system significantly affected the cause of fibrosis weak coal dust on the pulmonary surfactant system has a weak effect, the authors believe that the development of pulmonary surfactant system and pneumoconiosis have In a certain relationship, the early nonspecific inflammatory reaction in the lung may be related to the active function of the system.