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肝癌是我国常见恶性肿瘤之一,肝癌动物模型的建立,对肝癌的基础理论研究及实验治疗均有重要意义。我室于1978年将—615近交系小鼠的自发性肝细胞性肝癌移植成功建立了我国第一株小鼠可移植性肝癌模型(H615),并存建株过程中对其生物学特性进行了初步的观察,与此同时,重庆医学院范维珂等取其第9至20代瘤源进行了H615生物学性状的研究。迄今H615已传至34代,已稳定建株。为此,我们对建株后的H615正式进行了系统的实验研究,本文着重报告H615的生长规律。
Liver cancer is one of the common malignant tumors in our country. The establishment of animal model of liver cancer is of great significance to the basic theoretical research and experimental treatment of liver cancer. Our laboratory established the first mouse transplantable hepatocellular carcinoma model (H615) successfully in China in 1978 with transplanting of spontaneous hepatocellular carcinoma (HCC) of -615 inbred mice. The biological characteristics of H615 Preliminary observations, at the same time, Chongqing Medical College Fan Weike and other sources from 9 to 20 for H615 biological characteristics of the study. So far H615 has been transmitted to 34 generations, has been stable construction. To this end, we formally conducted a systematic experimental study of the H615 after establishment of a plant. This article focuses on the report of the growth pattern of H615.