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1.2,2,6,6-四(β-羧乙基)-環己酮經酯化後所生成的酯,可以作為合成各種二螺系化合物的原枓,在發生Dieckmann閉環作用後,即生成4,8-二(β-乙氧羰基)-二螺(5,1,5,3)十六三酮-3,7,11。再經水解失羧後,即得到二螺(5,1,5,3)十六三酮-3,7,11。這樣的三個六碳環的二螺環系,以前還沒有報導過。 2.二螺(5,1,5,3)十六三酮-3,7,11可以再和丙烯腈反應,生成2,2,4,4,10,10,12,12-八(β-氰基乙基)-二螺(5,1,5,3)十六三酮-3,7,11。利用這個化合物應當可以合成更複雜的螺系化合物。
1.2,2,6,6-Tetra (β-carboxyethyl) -cyclohexanone after esterification of the ester can be used as a synthesis of a variety of two spiro compounds of the original spine, in Dieckmann closed-loop effect, which is generated 4,8-Bis (β-ethoxycarbonyl) -bis (5,1,5,3) -hexadetrione-3,7,11. After hydrolysis by the decarboxylation, to obtain two spiro (5,1,5,3) -hexadecan-3,7,11. Such three six-carbocyclic spirocyclic systems have not previously been reported. Spiro (5,1,5,3) -hexadecan-3,7,11 can react with acrylonitrile to generate 2,2,4,4,10,10,12,12-octa (β - cyanoethyl) -bispiro (5,1,5,3) -hexadetrione-3,7,11. The use of this compound should make it possible to synthesize more complex spiro compounds.