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三、继发性肾脏病 1,狼疮肾炎播散性红斑性狼疮(SLE)是一病因未明、以多种免疫学异常为特征的疾病,发病率近年有增加之势,据泰国某医院报道,SLE占该院内科住院病人的3.3％。美国的Ooi在专题发言中指出,遗传与发病关系目前受到普遍重视。已证明不同的自身免疫性遗传学特征是由不同的基因控制的。在人类也已证明SLE的发病与HLA单型DrW_2及DrW_3有关。具有HLA单型B_6/DrW_3的正常人有FC受体功能缺陷。在SLE病人,C_3b受体也有减少。C_3b受体对免疫复合物(IC)的清除有重要作用,其外显率受遗传控制,常染色体显性遗传。遗传性补体缺陷也常见,补体也与IC的清除有关。 SLE病人肾脏损害十分常见。50～70％的SLE病人有狼疮肾炎(LN)的临床依据,
Third, secondary kidney disease 1, lupus nephritis Disseminated lupus erythematosus (SLE) is a disease of unknown etiology, characterized by a variety of immunological disorders, the incidence has increased in recent years, according to a Thai hospital reported that, SLE accounted for 3.3% of patients hospitalized in the hospital. Ooi in the United States pointed out in his keynote speech that the relationship between genetics and pathogenesis is currently receiving universal attention. It has been demonstrated that different autoimmune genetic features are controlled by different genes. In humans, the pathogenesis of SLE has also been shown to be related to HLA-type DrW_2 and DrW_3. Normal individuals with HLA haplotype B_6 / DrW_3 have FC receptor deficiencies. C_3b receptors are also reduced in SLE patients. The C_3b receptor plays an important role in the clearance of immune complexes (ICs), whose penetrance is genetically controlled and autosomal dominant. Hereditary complement defects are also common, complement and IC clearance related. SLE patients kidney damage is very common. 50 to 70% of SLE patients with lupus nephritis (LN) clinical basis,