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目的:探讨MMP-9在胰腺癌发生、发展及转移过程中的意义。方法:采用免疫组织化学S-P法,检测MMP-9在53例胰腺癌组织(胰腺癌组)及10例正常胰腺组织(对照组)中的表达,并与临床病理学资料进行分析比较。结果:胰腺癌组织中MMP-9的阳性表达明显高于正常胰腺组织(P<0.05)。MMP-9的表达与胰腺癌的临床分期及淋巴结有无转移有关(P<0.05)。结论:胰腺癌组织中MMP-9的表达与淋巴结转移及临床分期相关。
Objective: To investigate the significance of MMP-9 in the development, progression and metastasis of pancreatic cancer. Methods: The expressions of MMP-9 in 53 cases of pancreatic cancer (pancreatic cancer) and 10 cases of normal pancreatic tissue (control group) were detected by immunohistochemical S-P method and compared with clinicopathological data. Results: The positive expression of MMP-9 in pancreatic cancer tissues was significantly higher than that in normal pancreatic tissues (P <0.05). The expression of MMP-9 was correlated with the clinical stage of pancreatic cancer and lymph node metastasis (P <0.05). Conclusion: The expression of MMP-9 in pancreatic cancer is related to lymph node metastasis and clinical stage.