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用ＥＬＩＳＡ法测定了７１例脑血管病（ＣＶＤ）患者血浆氧化修饰低密度脂蛋白（ＯＭＬＤＬ）浓度，对比分析了患者血ＯＭＬＤＬ、甘油三酯（ＴＧ）、总胆固醇（ＴＣ）、高密度脂蛋白胆固醇（ＨＤＬＣ）、低密度脂蛋白胆固醇ＬＤＬＣ、载脂蛋白ＡⅠ（ａｐｏＡⅠ）、ａｐｏＢ１００的浓度、变化及异常率，并分析了ＯＭＬＤＬ浓度与其它指标的相关性。结果：ＣＶＤ患者血ＯＭＬＤＬ浓度显著高于对照组，ＬＤＬＣ浓度显著升高，ａｐｏＡⅠ浓度降低，而ＴＧ、ＴＣ、ＨＤＬＣ及ａｐｏＢ１００浓度无明显变化。除ＬＤＬＣ外，其余指标的异常率均显著低于ＯＭＬＤＬ。ＯＭＬＤＬ浓度与ａｐｏＡⅠ呈等级负相关（ｒＳ＝０．２８４，Ｐ＜０．０５），而与ＴＧ、ＴＣ、ＨＤＬＣ、ＬＤＬＣ及ａｐｏＢ１００无显著相关性。作者认为ＯＭＬＤＬ是目前脂代谢指标中最好的ＣＶＤ危险因素判别指标。
The serum levels of oxidized low density lipoprotein (OMLDL) in 71 patients with cerebrovascular disease (CVD) were measured by ELISA. The levels of OMLDL, triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDLC), low density lipoprotein cholesterol (LDLC), apolipoprotein A (apoAⅠ), apoB100 concentration and abnormal rate, and analyzed the relationship between OMLDL concentration and other indicators. Results: The blood OMLDL concentration in patients with CVD was significantly higher than that in the control group. The LDLC concentration was significantly increased, while the apoA Ⅰ concentration was decreased. There was no significant change in the concentrations of TG, TC, HDLC and apoB100. Except for LDLC, the abnormality rates of other indexes were significantly lower than those of OMLDL. OMLDL levels were negatively correlated with apoAI (rS = 0.284, P <0.05), but not with TG, TC, HDLC, LDLC and apoB100. The authors believe that OMLDL is the best indicator of CVD risk factors in lipid metabolism indicators.