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目的探讨L-选择素在缺血性脑卒中患者中的表达及其意义。方法选择缺血性脑卒中患者(病例组)和正常健康体检者(对照组)各50例,以甘油醛-3-磷酸脱氢酶(GAPDH)为内参,运用半定量RTPCR技术检测研究对象外周血中L-选择素的表达水平。结果与对照组比较,病例组L-选择素水平明显升高(2.96±0.71 vs 1.22±0.46,P<0.01)。结论 L-选择素在缺血性脑卒中患者外周血中表达增加,提示L-选择素可能与缺血性脑卒中的发病有关。
Objective To investigate the expression of L-selectin in patients with ischemic stroke and its significance. Methods Fifty patients with ischemic stroke (case group) and normal healthy subjects (control group), 50 patients with GAPDH as control group and semi-quantitative RTPCR technique were used to detect the peripheral The expression of L-selectin in the blood. Results Compared with the control group, the level of L-selectin in the patients increased significantly (2.96 ± 0.71 vs 1.22 ± 0.46, P <0.01). Conclusion The expression of L-selectin in the peripheral blood of patients with ischemic stroke increased, suggesting that L-selectin may be related to the pathogenesis of ischemic stroke.