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对32例骨巨细胞瘤的核DNA含量行流式细胞分析，以探讨该肿瘤的性质和分级。结果表明：Ⅰ级骨巨细胞瘤仍可看作是良性肿瘤，大多数DNA倍体水平正常；Ⅱ级骨巨细胞瘤有明确的恶性倾向，约三分之一的肿瘤DNA倍体水平异常；Ⅲ级骨巨细胞瘤则是恶性肿瘤，大部分肿瘤DNA倍体水平异常。另外，病理分级与肿瘤的S期细胞百分数及增殖细胞指数也有一定相关性，Ⅲ级骨巨细胞瘤有更大的细胞增殖活性。
The nuclear DNA content of 32 giant cell tumors of the bone was analyzed by flow cytometry to investigate the nature and grade of the tumor. The results showed that: Class I giant cell tumor of bone can still be considered as benign tumor, most DNA ploidy levels are normal; Class II giant cell tumor of bone has a clear malignant tendency, about one-third of the tumor DNA ploidy level is abnormal; Grade III giant cell tumor of bone is a malignant tumor, and the majority of tumors have abnormal DNA ploidy levels. In addition, the pathological grade and the S phase of the tumor cells and cell proliferation index also have a certain correlation, III giant cell tumor of bone has a greater cell proliferation activity.