【摘 要】
：
Difloxacin hydrochloride, one of aryl-fluoro quinolone antibiotic, has been synthesized in seven steps from 2, 4-dichloro-5-fluoroacetophenone via oxalylation,
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Difloxacin hydrochloride, one of aryl-fluoro quinolone antibiotic, has been synthesized in seven steps from 2, 4-dichloro-5-fluoroacetophenone via oxalylation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation and N-methylpiperazination. Additional four new intermediates are produced.
Difloxacin hydrochloride, one of aryl-fluoro quinolone antibiotics, has been synthesized in seven steps from 2, 4-dichloro-5-fluoroacetophenone via oxalylation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation and N-methylpiperazination. .
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