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目的:探讨胎盘生长因子(PLGF)及其受体血管内皮细胞生长因子受体-1(VEGFR-1,亦称可溶性受体-1,Flt-1)在早期宫颈鳞癌和癌前病变中的表达情况,结合临床资料分析其意义。方法:①采用免疫组化分别检测58例宫颈组织中的PLGF-1和Flt-1的表达。②结合临床资料分析PLGF-1/Flt-1在宫颈组织中的表达及其与疾病进展之间的关系。结果:①PLGF-1蛋白表达在癌前病变组阳性率为22.73%(5/22),浸润性鳞癌组为58.33%(21/36),其表达水平与临床分期显著相关(P<0.01),与淋巴结是否转移及细胞分化程度无关。②Flt-1仅在部分浸润性鳞癌组织中表达,阳性率为16.67%(6/36),其表达水平与临床分期和淋巴结是否转移均显著相关(P<0.01),与细胞分化程度无关。③在宫颈癌前病变和早期鳞癌组织中PLGF-1和Flt-1的表达存在一定的关联(P<0.05),但后者的表达水平显著低于前者。结论:PLGF-1/Flt-1在早期宫颈病变组织中的表达水平与临床分期密切相关,Flt-1可能是其发挥促进肿瘤转移的关键位点。
Objective: To investigate the expression of placental growth factor (PLGF) and its receptor vascular endothelial growth factor receptor-1 (VEGFR-1, also known as soluble receptor-1, Flt-1) in early cervical squamous cell carcinoma and precancerous lesions Expression, combined with clinical data analysis of its significance. Methods: ① Immunohistochemistry was used to detect the expression of PLGF-1 and Flt-1 in 58 cases of cervical tissue. ② The clinical data of PLGF-1 / Flt-1 expression in cervical tissue and its relationship with the progress of the disease. Results: (1) The positive expression rate of PLGF-1 protein in precancerous lesions was 22.73% (5/22) and that in invasive squamous cell carcinoma was 58.33% (21/36). The expression level of PLGF-1 was significantly correlated with clinical stage (P <0.01) , And lymph node metastasis and cell differentiation has nothing to do. ②Flt-1 was only expressed in some invasive squamous cell carcinomas, the positive rate was 16.67% (6/36). The expression level of Flt-1 was significantly correlated with clinical stage and lymph node metastasis (P <0.01), but not with cell differentiation. ③ There was a correlation between the expression of PLGF-1 and Flt-1 in cervical precancerous lesions and early squamous cell carcinoma (P <0.05), but the expression level of the latter was significantly lower than the former. CONCLUSION: The expression of PLGF-1 / Flt-1 in early cervical lesions is closely related to clinical stage. Flt-1 may be the key point of its role in promoting tumor metastasis.