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目的 多奇胶囊系由雌性金陵乌嘴鸭血和钙剂组成 ,在去势造成的骨质疏松症模型大鼠上观察了该药的药效学作用。结果显示 :1号胶囊能显著提高动物子宫系数 (P <0 0 5 )及骨密度值 (P <0 0 5和P <0 0 1) ,2号胶囊能增高模型动物血中雌二醇 (E2 )水平 (P <0 0 5 ) ,且两药均使模型动物血磷含量明显下降 (P <0 0 1) ,骨矿物质含量显著增高 (P <0 0 5或P <0 0 1)。这些结果表明 ,多奇胶囊能补充机体雌激素 ,维护骨质代谢 ,减少骨质丢失 ,具有防治骨质疏松的作用
Objective To observe the pharmacodynamic effects of the drug on the osteoporosis model rats induced by castration. The results showed that No. 1 capsules significantly increased the uterine coefficient (P <0 05) and bone mineral density (P <0 05 and P <0.01), and No. 2 capsules increased the blood level of estradiol in model animals (P <0.05). E2) level (P <0 05), both of which reduced the phosphorus content of model animals significantly (P <0 01), and the bone mineral content increased significantly (P <0 05 or P <0 01). . These results show that Dodge capsules can supplement the body’s estrogen, maintain bone metabolism, reduce bone loss, and have the effect of preventing and treating osteoporosis.