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Danazol 治疗宫内膜异位症、慢性囊性乳腺炎、乳腺痛、乳癌,遗传性血管性水肿、性早熟和作为可能的男、女性避孕药,多认为它能直接抑制促性腺激素分泌,还可能抑制性腺类固醇发生,与类固醇受体相互作用在靶器官及制止类固醇在血浆中结合。本文用 danazol 治疗宫内膜异位症并测定头四周的内分泌作用,试图弄清其作用方式。收治8例患者(23—35岁),腹腔镜检确诊为宫内膜异位症。1人为先天性无阴道,其余月经均规则。每天三次服用 danazol 共600mg。治疗前立刻收集血标本,后每隔一周测血一次共四周。测定
Danazol is thought to have a direct inhibitory effect on gonadotropin secretion in endometriosis, chronic cystic mastitis, breast pain, breast cancer, hereditary angioedema, precocious puberty and as potential male and female contraceptives May inhibit gonadal steroidogenesis, interact with steroid receptors in target organs, and stop steroid binding in plasma. In this paper, danazol treatment of endometriosis and determination of the first four weeks of endocrine role, trying to clarify its mode of action. Eight patients (23-35 years old) were admitted, and endoscopy was diagnosed as endometriosis. 1 person without congenital vaginal, the other menstrual rules. Take danazol a total of 600mg three times daily. Blood samples were collected immediately before treatment and blood was taken every other week for a total of four weeks. Determination