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目前采用的诊断帕金森病的临床标准对发现帕金森病综合征具有较高的敏感性,但是对于两者的鉴别特异性很差,而能可靠地用于临床和临床前帕金森病诊断的生化标志目前尚未发现。功能影像学提供了鉴别典型与非典型帕金森病的方法,揭示了多巴胺能神经元功能缺陷方式。研究表明,在帕金森病早期和仅有几年时间的临床前潜伏期内,多巴胺能神经元末梢功能以每年4％～12％的速率丧失。功能影像学将在评估神经保护剂疗效中发挥越来越重要的作用。
The clinical criteria currently used to diagnose Parkinson’s disease are highly sensitive to the discovery of Parkinson’s disease syndrome but poorly discriminate between the two and can be reliably used in the diagnosis of both preclinical and preclinical Parkinson’s disease Biochemical markers have not yet been found. Functional imaging provides a method of identifying typical and atypical Parkinson’s disease, revealing the mode of functional deficit in dopaminergic neurons. Studies have shown that dopaminergic neuronal peripheral function is lost at rates of 4% to 12% per year during preclinical latency in the early stages of Parkinson’s disease and in only a few years. Functional imaging will play an increasingly important role in assessing the efficacy of neuroprotective agents.