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目的 探讨急性肾衰患者血清β_２－微球蛋白（βＭＧ）和乳酸脱氢酶（ＬＤＨ）水平的变化及其临床意义。方法 用放射免疫法测定６０例急性肾衰患者少尿期、多尿期、临床治愈期及愈后１个月，血清β-２－ＭＧ和ＬＤＨ含量并与３０例健康人作对照。结果 肾衰患者血清β_２－ＭＧ为１９．６４±３．１８ｍｇ／Ｌ，ＬＤＨ为１０５２．２２±１７５．４７Ｕ／Ｌ，均明显高于健康对照组。结论 急性肾衰患者存在高β_２－ＭＧ和ＬＤＨ，且β_２－ＭＧ和ＬＤＨ与病情轻重和疾病转归密切相关。测定血β_２－ＭＧ和ＬＤＨ可作为判断病情严重程度、预测患者病情发展的客观指标。
Objective To investigate the changes of serum β_2-microglobulin (βMG) and lactate dehydrogenase (LDH) in patients with acute renal failure and its clinical significance. Methods The serum levels of β-2-MG and LDH in 60 patients with acute renal failure were detected by radioimmunoassay in the period of oliguria, polyuria, clinical healing and 1 month after the treatment. The results were compared with 30 healthy controls. Results Serum β_2-MG of patients with renal failure was 19.64 ± 3.18mg / L and LDH was 1052.22 ± 175.47U / L, which were significantly higher than those of healthy controls. Conclusion There are high β_2-MG and LDH in patients with acute renal failure, and β_2-MG and LDH are closely related to the severity and disease outcome. Measurement of blood β_2-MG and LDH can be used as an objective indicator to judge the severity of the disease and predict the progression of the patient’s condition.