ＶＨＬ基因是１９９３年被鉴定的肿瘤抑制基因，其抑癌作用主要表现在基因转录水平，通过抑制ＥｌｏｎｇｉｎＡＢＣ复合体的形成来实现，对其结构与功能的进一步研究表明，ＶＨＬ基因在控制细胞周期、基因组的稳定、细胞的死亡及其它肿瘤的发生发展的相关方面起着一定的作用。ＶＨＬ基因在ＶＨＬ疾病及散发的非遗传型肾细胞癌具有较高的突变率，在肾细胞癌的诊断与治疗上具有重要的应用价值 VHL gene was identified in 1993 tumor suppressor gene, its tumor suppressor effect mainly in the gene transcription level, by inhibiting the formation of ElonginABC complex to achieve its structure and function of further studies have shown that VHL gene in the control of cell cycle, Genome stability, cell death and other related aspects of tumor development play a role. VHL gene in VHL disease and dissemination of non-genetic type of renal cell carcinoma with a high mutation rate in the diagnosis and treatment of renal cell carcinoma has important application value