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观察了槲皮素（Qu）对不同病程糖尿病（DM）大鼠主动脉胶原非酶糖化的抑制作用，并与氨基胍（AG）作对比。结果：Qu（100mg·kg-1／d）灌胃治疗9周，能明显抑制主动脉胶原及胶原交联的AGEs含量，与等剂量AG作用相近，但起效要晚。Qu有一定的降压作用，但对血糖及血清果糖胺无影响。提示Qu能通过抑制胶原非酶糖化来防治DM血管病变。
The inhibitory effect of quercetin on nonenzymatic glycation of aorta collagen in rats with different duration of diabetes mellitus was observed and compared with aminoguanidine (AG). Results: Qu (100 mg · kg-1 / d) administered orally for 9 weeks significantly inhibited the AGEs content of collagen and collagen cross-linked by aorta, which was similar to the effect of equal dose of AG, but its effect was late. Qu has a certain antihypertensive effect, but no effect on blood glucose and serum fructosamine. Tip Qu can prevent collagen non-enzymatic glycation to prevent DM vascular disease.