氯苯吩嗪用于治疗麻风病已十多年,除了皮肤红染外至今未见到严重的副作用。Mackey报道用该药治疗慢性盘状红斑狼疮(DLE)2G例中有17例减轻。作者选择10例经活检证实的临床上活动的DLE患者,都对以前的治疗不满意,每日用氯苯盼嗪100毫克,计每月从临床上对其疗效作出评价。在治疗开始前作全血计数和肝肾功能生化检查,在3月和6月时复查化验。在试验期间不用其他药物治疗。 Chlorphenothiazine has been used for the treatment of leprosy for more than a decade, with no serious side effects other than skin red staining. Mackey reports that 17 of the 2G patients treated with this drug for chronic discoid lupus erythematosus (DLE) were relieved. The authors selected 10 clinically active DLE patients who had been biopsied and were dissatisfied with previous treatments. Each patient was given 100 mg of metophotazine once daily for clinical evaluation of their efficacy. Before the start of treatment for whole blood count and liver and kidney biochemical tests, in March and June review of the test. No other medications were used during the trial.