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瘦素由美国洛克菲勒大学Friedman领导的实验室成员Zhang在1994年首先发现,他们采用位置克隆技术对小鼠的肥胖基因和人类的同源系列进行分子克隆系列测定,发现瘦素是一条含167个氨基酸的DNA系列,全长20KB,包含2个内显子,3个外显子,是肥胖基因编码的多肽激素,主要由脂肪细胞分泌。瘦素可能通过血脑屏障,与下丘脑特异性受体结合而发挥生理作用,通过抑制食欲,减少能量摄取,增加能量消耗,抑制
Leptin A laboratory member led by Friedman at Rockefeller University in the United States first discovered in 1994 that they used positional cloning to perform a molecular cloning series of mouse obesity genes and human homologues and found that leptin, Amino acid DNA series, full-length 20KB, contains two exons, three exons, is a polypeptide encoded by obesity genes hormones, mainly by the secretion of fat cells. Leptin may play a physiological role by binding to the hypothalamic-specific receptors through the blood-brain barrier, by suppressing appetite, decreasing energy intake, increasing energy expenditure, inhibiting