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目的观察冠心病稳定性心绞痛患者血浆髓过氧化物酶(MPO)水平。方法选择2个种族的573例已行冠状动脉造影患者,其中295例为冠心病稳定性心绞痛组(SAP组),278例非冠心病稳定性心绞痛为对照组。分别测血浆MPO水平及空腹血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、葡萄糖、空腹血浆胰岛素、脂联素、纤维蛋白原、超敏C反应蛋白和Ⅶ因子浓度,并采用Spearman法对冠心病稳定性心绞痛的危险因素进行相关性分析。结果MPO水平SAP组为126．3(95．8～160．2)mg/L,对照组为123．6(97．4～150．0)mg/L,差异无统计学意义(P＞0．05)；黑人男性、白人男性、黑人女性及白人女性MPO水平分别为119．6(94．8～146．9)、124．6(99．9～154．6)、124．0(93．3～152．3)mg/L及127．5(95．3～159．8)mg/L,4组比较差异无统计学意义(P＞0．05)。MPO水平与Ⅶ因子(r=0．251,P＜0．01)、空腹血糖(r=0．095,P＜0．05)、甘油三酯(r=0．186,P＜0．01)、总胆固醇(r=0．081,P＜0．05)、超敏C反应蛋白(r=0．123,P＜0．01)和纤维蛋白原(r=0．077,P＜0．01)呈正相关；与脂联素(r=0．115,P＜0．01)呈负相关。结论冠心病稳定性心绞痛患者血浆MPO水平未升高,不是冠心病稳定性心绞痛患者的预测因子,且在性别、种族间无差异。
Objective To observe the level of plasma myeloperoxidase (MPO) in patients with coronary heart disease and stable angina pectoris. Methods A total of 573 patients undergoing coronary angiography were enrolled in this study. Among them, 295 were stable angina pectoris patients (SAP group) and 278 patients with stable angina pectoris without coronary heart disease were controls. Plasma MPO levels and fasting plasma total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, glucose, fasting plasma insulin, adiponectin, fibrinogen, high sensitivity C-reactive protein , And using Spearman method to analyze the risk factors of coronary heart disease with stable angina. Results The level of MPO in SAP group was 126.3 (95.8 ~ 160.2) mg / L, while the control group was 123.6 (97.4 ~ 150.0) mg / L, with no significant difference (P> 0 .05). The levels of MPO in black, white, black and white women were 119.6 (94.8-146.9), 124.6 (99.9-154.6) and 124.0 .3 ~ 152.3) mg / L and 127.5 (95.3 ~ 159.8) mg / L respectively. There was no significant difference between the four groups (P> 0.05). The level of MPO was positively correlated with the level of factor Ⅶ (r = 0.251, P <0.01), fasting blood glucose (r = 0.095, , Total cholesterol (r = 0.081, P <0.05), high sensitivity C reactive protein (r = 0.123, P <0.01) and fibrinogen .01), but negatively correlated with adiponectin (r = 0.115, P <0.01). Conclusions Plasma MPO level is not elevated in patients with stable angina pectoris, and is not a predictor of stable angina pectoris in patients with coronary heart disease. There is no difference in sex and race.