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目的:探讨可溶性热休克蛋白60(sHSP60)与实验大鼠主动脉粥样硬化的关系及药物对其影响。方法:建立大鼠动脉粥样硬化模型,随机分为对照组、高脂组、血脂康组及阿司匹林组,并对其血脂水平、血清sHSP60进行检测,应用苏木精-伊红及油红O染色观察各组血管形态学变化。结果:血脂康组血脂水平较高脂组及阿司匹林组明显降低,阿司匹林组sHSP60水平较高脂组及血脂康组明显下降;血脂康组和阿司匹林组血管脂质沉积较高脂组减少。结论:sHSP60可能是与血脂水平无关的动脉粥样硬化预测因子;血脂康、阿司匹林均可有效减少血管壁脂质沉积。
Objective: To investigate the relationship between soluble heat shock protein 60 (sHSP60) and aortic atherosclerosis in rats and the effect of drugs on it. Methods: The model of atherosclerosis in rats was established and randomly divided into control group, hyperlipidemia group, Xuezhikang group and aspirin group. The levels of serum lipids and serum sHSP60 were detected. The hematoxylin and eosin and oil red O The morphological changes of blood vessels in each group were observed by staining. Results: Serum lipid levels in Xuezhikang group were significantly lower than those in the high-fat group and aspirin group. The levels of sHSP60 in aspirin group were significantly lower than those in the high-fat group and the Xuezhikang group. Blood lipid deposition in Xuezhikang group and aspirin group was lower than that in the high-fat group. CONCLUSIONS: sHSP60 may be a predictor of atherosclerosis independent of serum lipids. Xuezhikang and aspirin may reduce lipid deposition in the blood vessel wall.