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目的:研究吴茱萸次碱对离体大鼠室颤阈的影响。方法:离体心脏采用Langendorff恒流灌流,分别予溶媒、低剂量吴茱萸、高剂量吴茱萸处理5min并记录处理前后心率,采用S1S2法测量有效不应期,采用串刺激法测量室颤阈。结果:与溶媒组相比,低剂量组、高剂量组的有效不应期和室颤阈均无显著性差异。结论:吴茱萸次碱对离体大鼠室颤阈没有明显的影响。
Objective: To study the effect of rutacarpine on ventricular fibrillation threshold in isolated rat. METHODS: Isolated Langendorff perfused hearts were used for perfusion. The rats were treated with vehicle, low-dose Evodia rutaecarpa and high-dose Evodia rutaecarpa for 5 min. The heart rate before and after treatment was recorded. The effective refractory period was measured by S1S2 method. The ventricular fibrillation threshold was measured by string stimulation. RESULTS: Compared with the vehicle group, there was no significant difference in effective refractory period and ventricular fibrillation threshold between the low-dose group and the high-dose group. Conclusion: Erigeron has no obvious effect on the ventricular fibrillation threshold in isolated rat.