莱姆病是一种以硬蜱作为传播媒介、由伯氏疏螺旋体感染所致的人兽共患传染病,临床表现多样,严重影响人类健康和生活质量。有关细胞因子在莱姆病发生发展中的作用尚未完全阐明,但国内外已经取得一系列研究进展。明确不同类型细胞因子在莱姆病中的作用不仅有利于揭示莱姆病发生发展的具体分子机制,还将大大促进细胞因子在莱姆病预防、诊断和药物治疗中的应用。现就细胞因子与莱姆病关系的研究作一综述。 Lyme disease is a zoonosis infection caused by Borrelia burgdorferi with Ixodidae as a transmission medium. It has various clinical manifestations and seriously affects human health and quality of life. The role of cytokines in the development of Lyme disease has not yet been fully elucidated, but a series of research progresses have been made at home and abroad. To clarify the role of different types of cytokines in Lyme disease is not only conducive to reveal the specific molecular mechanism of the development of Lyme disease, but also greatly promote the cytokine in Lyme disease prevention, diagnosis and drug treatment. Now on the relationship between cytokines and Lyme disease are reviewed.