论文部分内容阅读
Nogo-A的活性部位可能有两个,位于两个疏水区域之间的Nogo-66和氨基末端到第一个疏水结构域这部分肽链,即amino-Nogo;NgR属糖基磷脂酰肌醇锚定蛋白,具有多个富亮氨酸的重复结构。Nogn-A主要表达于中枢神经系统,位于在投射神经元和形成髓鞘的少突胶质细胞中,在胞膜,胞质和胞核中都存在。许多研究表明,Nogo-A和NgR在轴突生长的过程中就有表达;细胞核上免疫金标记的Nogo-A主要存在于染色体的核小体上,表明它可能与基因转录有关;Nogo-A的表达与一些髓鞘形成有关的因子如α-微管蛋白 髓鞘基础蛋白(MBP)的表达有密切联系,这也暗示Nogo-A可能与髓鞘形成有关。通过进一步研究阐明它的功能是有必要的。
Nogo-A may have two active sites located between the two hydrophobic regions of Nogo-66 and the amino-terminal to the first hydrophobic domain of this part of the peptide chain, namely amino-Nogo; NgR is a glycosyl phosphatidylinositol Anchored proteins, with multiple leucine-rich repeat structures. Nogn-A is mainly expressed in the central nervous system, located in the projecting neurons and the formation of myelin oligodendrocytes, in the membrane, cytoplasm and nuclei exist. Many studies have shown that Nogo-A and NgR are expressed during axonal growth. The immunogold labeled Nogo-A on the nucleus is mainly located on chromosome nucleosomes, indicating that it may be involved in gene transcription. Nogo-A Expression is closely related to the expression of some myelin-related factors such as α-tubulin myelin basic protein (MBP), which also suggests that Nogo-A may be involved in myelination. It is necessary to clarify its function through further research.