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在高压氧防治声损伤的研究过程中,我们发现高压氧对125分贝3小时强声暴露引起的豚鼠声损伤,具有明显的预防作用,但未见治疗效果。我们考虑高压氧不显治疗效果,是否同试验中使用的声音剂量过大有关系,若使用低于此声音剂量引起的声损伤,给以高压氧,其治疗效果和预防作用又如何? 为此,我们设计了两批实验,即采用两个声音剂量等级,1KHz纯音120分贝0.5小时声暴露和1KHz纯音115分贝0.5小时声暴露。每批实验所选用的动物均为耳廓反应灵敏,鼓膜正常,体重在255～350克范围内的豚
In the process of hyperbaric oxygen prevention and treatment of acoustic damage, we found that hyperbaric oxygen had a significant preventive effect on guinea pig sound damage caused by intensive exposure of 125 db for 3 hours, but no therapeutic effect was found. We consider whether the effect of hyperbaric oxygen treatment is significantly related to the amount of sound used in the test. If the use of hyperbaric oxygen is less than the sound dose, what is the therapeutic and preventive effect? , We designed two batches of experiments, using two sound dose levels, 1 kHz pure tone 120 dB 0.5 hour sound exposure and 1 kHz pure sound 115 dB 0.5 hour sound exposure. The animals selected for each batch of experiments were sensitive to the auricles, normal eardrum, and the body weight was in the range of 255-350 g