阿糖胞苷是应用广泛的抗代谢类抗肿瘤药,用药后除会引起骨髓抑制、胃肠道反应外,尚有发热、脱发、皮疹、肝功能损伤等药品不良反应(ADR)。鞘内注射化疗药物是临床上预防和治疗中枢神经性白血病(CNSL)最常用最有效的方法之一,但不可否认的是,该给药方式增加了化疗药物不良反应的 Cytarabine is a widely used anti-tumor antineoplastic agent. Adverse drug metabolism (ADR) such as fever, hair loss, rash and liver damage are found in addition to bone marrow suppression and gastrointestinal reactions. Intrathecal chemotherapeutic drugs are one of the most commonly used and most effective methods for the prevention and treatment of central nervous leukemia (CNSL) clinically, but it is undeniable that this mode of administration increases the adverse effects of chemotherapeutic drugs