论文部分内容阅读
目的探讨先天性弓形虫感染对儿童学习和记忆的远期影响,为先天性弓形虫病防治和康复提供指导。方法选建保健册孕妇分娩的、现读中学儿童作为研究对象,应用酶联免疫吸附法(ELISA)检测孕妇外周血弓形虫IgM,CAg,对弓形虫IgM,CAg阳性孕妇,检查新生儿脐血弓形虫IgM,CAg,根据婴儿出生时脐血弓形虫检测结果分感染阳性组(感染组孕妇生小儿IgM或CAg阳性),感染阴性组(感染组孕妇生小儿IgM和CAg阴性)和非感染组(非感染组孕妇生小儿);选择愿意合作感染阳性组60例,分治疗和不治疗各30例,比较干预效果。采用简明精神状况调查量表(MMSE)、汉诺塔测试和威斯康星卡片分类测试进行神经心理学检查。结果在MMSE测试中,阳性未治组在回忆能力、计算力以及总分测试中得分显著低于非感染组(P<0.05)。学习前,在TOH和WCST测试中,阳性未治组与非感染组差异有统计学意义(P<0.05);阳性未治组与治疗组差别有统计学意义,(P<0.05)。学习后,阳性治疗组、阳性未治组TOH得分与学习前差别无统计学意义(P>0.05),阳性未治组WCST测定指标差异有统计学意义(P<0.05)。结论弓形虫感染出生儿童脑部功能受到损害,早期治疗和训练后好转,干预措施有效。
Objective To investigate the long-term effects of congenital Toxoplasma gondii infection on learning and memory in children and provide guidance for the prevention and treatment of congenital toxoplasmosis. Methods Select health book delivery of pregnant women, secondary school children are now study as the object, the application of enzyme-linked immunosorbent assay (ELISA) detection of pregnant women, peripheral blood toxoplasma IgM, CAg, Toxoplasma gondii IgM, CAg positive pregnant women, check the newborn cord blood Toxoplasma gondii IgM, CAg, according to the results of cord blood test of Toxoplasma gondii in infants positive group (positive IgM or CAg positive in pregnant women in infected group), negative group (negative IgM and CAg in pregnant women in infected group) and non-infected group (Non-infected group of pregnant women and children); choose to cooperate positive group 60 cases, divided into treatment and no treatment of 30 cases, the intervention effect. Neuropsychological tests were performed using the Concise Mental Status Survey (MMSE), the Hanoi Test and the Wisconsin Card Classification Test. Results In the MMSE test, the scores of recall, calculation and total score in the non-infected group were significantly lower than those in the non-infected group (P <0.05). Before TOH and WCST test, the difference between positive control group and non-infected group was statistically significant (P <0.05). The difference between positive control group and treatment group was statistically significant (P <0.05). After learning, there was no significant difference in TOH score between the positive treatment group and the positive control group (P> 0.05), but there was no significant difference between the positive control group and the control group (P <0.05). Conclusion The brain function of born children infected with Toxoplasma gondii is impaired. After early treatment and training, the brain function is improved and the intervention measures are effective.