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作者用胰岛素免疫细胞化学染色确立胰岛素瘤的诊断,通过嗜银核仁组成区法(AgNORs)测定胰岛素瘤的增生活性,研究了22例胰岛素瘤患者术前空腹血糖浓度与该瘤增生活性的关系。AgNORs值从1.05到3.25,血糖浓度从0.7到5.9mmol/L,并且发现,两者之间存在着非常显著的正相关(r=0.813,P<0.001)。这表明,AgNORs值愈小,即生长活性愈低,患者血糖浓度亦愈低,该瘤功能则愈高;反之,AgNORs值愈大,即生长活性愈高,患者血糖浓度也愈高,该瘤功能则愈低,其增生活性则愈高,这对认识该瘤生物学行为具有实际意义。
The authors used insulin immunocytochemical staining to establish the diagnosis of insulinoma. The proliferative activity of insulinoma was determined by AgNORs. The relationship between the fasting blood glucose and the proliferative activity of the tumor before operation in 22 patients with insulinoma . The AgNORs ranged from 1.05 to 3.25 and the blood glucose concentrations ranged from 0.7 to 5.9 mmol / L. There was a very significant positive correlation (r = 0.813, P <0.001) between the two. This indicates that the smaller the value of AgNORs, the lower the growth activity, the lower the blood glucose level of the patient and the higher the tumor function. Conversely, the larger the AgNORs value is, the higher the growth activity is and the higher the blood glucose level of the patient is The lower the function, the higher its proliferative activity, which is of practical significance for understanding the biological behavior of the tumor.