顺铂和氟脲嘧啶白蛋白微球颈外动脉栓塞化疗治疗头颈部晚期癌

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选择性动脉注射抗癌药微球的方法称栓塞化疗,因其具有阻断肿瘤供血和提高局部药物浓度及延长药物活性的双重作用,故对治疗恶性肿瘤有明显疗效。本文采用预外动脉分支注射顺铂白蛋白微球和5-Fu微球的栓塞化疗方法治疗晚期头颈部肿瘤共10例,取得显著效果:10例中有1例肿块完全消退,9例肿块部分消退(肿块缩小在30~70%);有4例随后施行了根治性手术。随访时间最短26个月,最长44个月,到最后随访时间为止,有5例死亡,5例健在。本文认为,颈外动脉分支注射顺铂微球和5-Fu微球的栓塞化疗方法对治疗晚期头颈肿瘤不失为一种有效的术前辅助手段或一种姑息治疗方法。 The method of selective arterial injection of anti-cancer drug microspheres is called embolization chemotherapy because it has dual functions of blocking tumor blood supply and increasing local drug concentration and prolonging drug activity, so it has obvious curative effect on the treatment of malignant tumors. In this article, 10 cases of advanced head and neck tumors were treated with the method of embolization of cisplatin albumin microspheres and 5-Fu microspheres with pre-external arterial branch injection. Significant results were obtained: 1 out of 10 cases completely disappeared, and 9 cases were lumps. Partial regression (tumors shrinking at 30-70%); 4 cases were followed by radical surgery. The shortest follow-up period was 26 months and the longest was 44 months. Five deaths were reported and 5 patients were still alive until the final follow-up period. This article believes that the external carotid artery injection of cisplatin microspheres and 5-Fu microsphere embolization chemotherapy for the treatment of advanced head and neck tumors is an effective preoperative assistant or a palliative treatment.
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